| 发明名称 |
CONTROLLED RELEASE PEPTIDE FORMULATIONS |
| 摘要 |
The present invention relates to compositions forming a low viscosity mixture of: a) 20-80 wt. % of at least one diacyl glycerol and/or a tocopherol; b) 20-80 wt. % of at least one phosphatidyl choline (PC); c) 5-20 wt. % of at least one biocompatible, organic mono-alcoholic solvent; d) up to 20 wt. % polar solvent e) at least one peptide active agent; f) optionally at least one antioxidant; wherein the ratio of components a:b is in the range 40:60 to 54:46; wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with excess aqueous fluid. The invention further relates to methods of treatment comprising administration of such compositions, and to pre-filled administration devices and kits containing the formulations. |
| 申请公布号 |
US2014162944(A1) |
申请公布日期 |
2014.06.12 |
| 申请号 |
US201214117994 |
申请日期 |
2012.05.25 |
| 申请人 |
Tiberg Fredrik;Nistor Catalin;Johnsson Markus |
发明人 |
Tiberg Fredrik;Nistor Catalin;Johnsson Markus |
| 分类号 |
A61K47/24;A61K38/31;A61K47/10 |
主分类号 |
A61K47/24 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A pre-formulation comprising a low viscosity mixture of:
a) 20-80 wt. % of at least one diacyl glycerol and/or a tocopherol; b) 20-80 wt. % of at least one phosphatidyl choline (PC); c) 5-20 wt. % of at least one biocompatible, organic mono-alcoholic solvent; d) up to 20 wt. % polar solvent e) at least one peptide active agent; f) optionally at least one antioxidant; wherein the ratio of components a:b is in the range 40:60 to 54:46; wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with excess aqueous fluid.
|
| 地址 |
Lund SE |
