A novel process is provided for the efficient preparation of an asymmetric compound of structural formula I: comprising a copper-catalyzed, carbon-nitrogen cross-coupling step. The process described as part of the present invention can be used to manufacture poly (ADP-ribose) polymerase (PARP) inhibitors, which may be useful for the treatment of cancer. In particular, the present invention describes a process for the manufacture of the PARP inhibitor, 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide.
申请公布号
WO2014088983(A1)
申请公布日期
2014.06.12
申请号
WO2013US72710
申请日期
2013.12.03
申请人
MERCK SHARP & DOHME CORP.;CHUNG, CHEOL, K.;SCOTT, MARK, E.;BULGER, PAUL GERARD;BELYK, KEVIN MICHAEL;LIMANTO, JOHN;HUMPHREY, GUY, R.
发明人
CHUNG, CHEOL, K.;SCOTT, MARK, E.;BULGER, PAUL GERARD;BELYK, KEVIN MICHAEL;LIMANTO, JOHN;HUMPHREY, GUY, R.