Copolymer including uncharged hydrophilic block and cationic polyamino acid block having hydrophobic group in part of side chains, and use thereof

摘要

Disclosed is a block copolymer including an uncharged hydrophilic polymer chain block, and a cationic polyamino acid chain block. In the copolymer, a hydrophilic polymer chain block is combined with an end of any one of main chains of the polyamino acid chain block via covalent binding, and a hydrophobic radical is combined with a lateral chain having 10 to70 amino acid repeating units in the polyamino acid chain block via covalent binding. The copolymer provides a stable aggregate with the siRNA, small molecule nucleic acid, under a physiologic condition.