STAPHYLOCOCCUS AUREUS DIV1B FOR USE AS VACCINE

摘要

The invention relates to an antigenic polypeptide referred to as DivIB and variants thereof, vaccines and immunogenic compositions comprising said polypeptide and the use of the vaccines and/or immunogenic compositions in the treatment and prevention of microbial infections.

主权项

1. A method to immunize an animal subject against a microbial infection comprising administering an immunogenic composition comprising a polypeptide selected from the group consisting of:
i) a polypeptide encoded by a nucleotide sequence of SEQ ID NO: 1, 3 or 5, or an antigenic fragment thereof; ii) a polypeptide encoded by a nucleotide sequence wherein said sequence is degenerate as a result of the genetic code to a nucleotide sequence of SEQ ID NO: 1, 3 or 5; iii) a polypeptide comprising an amino acid sequence encoded by SEQ ID NO: 2, 4 or 6; iv) a polypeptide comprising an amino acid sequence that varies from a sequence of SEQ ID NO: 2, 4 or 6 by addition deletion or substitution of at least one amino acid residue; and v) a polypeptide comprising an amino acid sequence that is at least 85% identical to an amino acid sequence of SEQ ID NO: 2, 4 or 6.