PON1 AS A MARKER FOR HEART FAILURE

摘要

Provided herein are methods for assessing the risk a test subject with heart failure has of experiencing a major adverse cardiac event, requiring revascularization, requiring a heart transplant, requiring unscheduled hospitalization for heart failure, progression of heart failure status, or any combination thereof. Also provided herein are methods for assessing the risk a test subject has of developing heart failure. The present methods comprise determining the levels of paraoxonase 1 activity in the serum, non-chelated plasma, or both in the test subject and comparing the level of PON1 activity in the test subject's sample with a control or baseline value based on levels of PON1 activity in serum, non-chelated plasma, or both samples from a population of control subjects. Also provided herein are kits useful in assessing such risks.

主权项

1. A method for assessing a risk of progression of heart failure status in a test subject comprising:
determining a level of paraoxonase 1 (PON1) activity in a serum or non-chelated plasma sample from the test subject; and comparing the level of PON1 activity in the test subject's serum or non-chelated plasma sample with a control or baseline value based on levels of PON1 activity in serum or non-chelated plasma samples from a population of control subjects, wherein a test subject whose level of PON1 activity is less than the control or baseline value is at risk of progression of heart failure status.