发明名称 |
Reconstitutable Microsphere Compositions Useful As Ultrasonic Contrast Agents |
摘要 |
Methods and suspensions are provided that are useful for preparing readily reconstitutable, dry compositions of micro- or nanospheres. The dry compositions find use in diagnostic applications such as ultrasonic imaging. The suspension includes as key ingredients one or both of t-butyl alcohol and/or an amorphous sugar (or mixture of amorphous sugar) in specified amounts that reduce aggregation of the particles comprising the suspension. |
申请公布号 |
US2014161726(A1) |
申请公布日期 |
2014.06.12 |
申请号 |
US201213712192 |
申请日期 |
2012.12.12 |
申请人 |
Ottoboni Thomas B.;Short Robert E. |
发明人 |
Ottoboni Thomas B.;Short Robert E. |
分类号 |
A61K49/22 |
主分类号 |
A61K49/22 |
代理机构 |
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代理人 |
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主权项 |
1. An aqueous particle suspension comprising:
a) a plurality of particles in an amount of 0.3 to 4 mg per milliliter of suspension; b) one or more amorphous sugars at a total weight to weight ratio (wt amorphous sugars:wt particles) in the range of 0.5:1 to 12:1 for hollow-cored particles (based upon the shell weight of the particles) or 0.02:1 to 0.86:1 for solid-cored particles; and c) t-butyl alcohol at a weight to weight ratio (t-butyl alcohol:particles) in the range of 30:1 to 600:1 for hollow-cored particles or 2:1 to 43:1 for solid-cored particles.
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地址 |
Belmont CA US |