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1. A GIP analog derived from GIP (1-29, SEQ ID NO: 1), wherein GIP analog has both GLP-1 agonist activity and GIPR stimulation activity, and comprises an amino acid sequence represented by the following formula I:
Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13-A14-A15-Lys-A17-A18-A19-A20-A21-A22-A23-A24-Trp-Leu-A27-A28-A29-Ywherein
A1 is selected from the group consisting of Ala, Gly, Sarcosine, Aib, d-Ala and d-Ser; A3 is selected from the group consisting of Glu and Gln; A7 is selected from the group consisting of Thr, Ile and Ser; A12 is selected from the group consisting of Ile, Glu and Asp; A13 is selected from the group consisting of an amino acid residue having aryl group and is selected from Tyr, Phe, Phe(4-F), Phe(4-NO2), Phe(4-NH7), Ala, Ala(2-thienyl), Ala(benzothienyl), Ala(4-Pyridyl) and phenylglycine; A14 is selected from the group consisting of Met or oxidized Met, Leu, Val, Norleucine and Ile: A15 is selected from the group consisting of Glu and Asp; A17 is selected from the group consisting of Ile, Gln, and Gln; A18 is selected from the group consisting of Ala and His; A19 is selected from the group consisting of Val, Ala, Leu, Gln and Ile; A20 is selected from the group consisting of Arg, Lys-Z, Gln, Glu, Asp and Cys-Z; A21 is selected from the group consisting of Glu, Asp and Leu; A22 is selected from the group consisting of Phe, Phe(4-F), Phe(4-Cl), Tyr, Tyr(4-Me) and Nal; A23 is selected from the group consisting of Ile and Val; A24 is selected from the group consisting of Ala, Asn, Gln, Lys-Z and Cys-Z; A27 is selected from the group consisting of Val, Len, Ala, and Lys-Z; A28 is selected from the group consisting of Lys-Z, Ala, Arg, and Asn; A29 is selected from the group consisting of Gly, Gln and Arg; Y is selected from the group consisting of: A30 and -Gly-Pro-Ser-Ser-GI-Ala-Pro-Pro-Pro-Ser-A40, or absent; A30 and A40 are independently selected from the group consisting of -(Lys)n-Z and -Cys-Z, or absent; Z is selected from the group consisting of -(Glu)m-PEG, -(Glu)m-biotin and -(Glu)m-fatty acid, or absent; n is an integer selected from 1 to 6; m is an integer selected from 0 to 3; wherein, a lactam linkage is optionally formed between the amino acids at positions i and i+4 of the GIP analog; i is an integer selected from 12 to 24; or a pharmaceutically acceptable salt thereof.
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