| 摘要 |
An object of the present invention is to provide a method for reducing a halogenobenzoic acid ester, in which dehalogenation is inhibited, by using a readily available catalyst. The method comprises reducing an ester with hydrogen gas by using an aromatic hydrocarbon as a solvent in the presence of a ruthenium complex represented by the following general formula (1):;RuXY(CO)(L) (1)where X and Y represent monovalent anionic ligands, and L represents a tridentate aminodiphosphine ligand represented by the following general formula (2):;where RZ1 represents an alkyl group having 1 to 4 carbon atoms, each RZ2 represents an alkyl group having 1 to 4 carbon atoms or a halogen atom, any adjacent two RZ2s may form a ring, Hal represents a halogen atom, and n represents 0 to 4. |
| 主权项 |
1. A reduction method, in which dehalogenation is inhibited, the method comprising reducing a halogenobenzoic acid ester in an aromatic hydrocarbon solvent in the presence of a ruthenium complex to thereby produce an alcohol compound,
the ruthenium complex being represented by the following general formula (1):
RuXY(CO)(L) (1), wherein X and Y, which may be the same or different, each represent a monovalent anionic ligand, and L represents a tridentate aminodiphosphine ligand represented by the following general formula (2): wherein R1, R2, R3, and R4, which may be the same or different, each represent a hydrogen atom, an alkyl group, a cycloalkyl group, an aryl group, an aralkyl group, an alkoxy group, a cycloalkyloxy group, an aryloxy group, an aralkyloxy group, a heterocyclic group, or a substituted amino group, each of the pair of R1 and R2 and the pair of R3 and R4 may be bonded to each other to form a ring together with the corresponding adjacent phosphorus atom, and the alkyl group, the cycloalkyl group, the aryl group, the aralkyl group, the alkoxy group, the cycloalkyloxy group, the aryloxy group, the aralkyloxy group, and the heterocyclic group are optionally substituted, and Q1 and Q2, which may be the same or different, each represent an optionally substituted divalent alkylene group, an optionally substituted divalent cycloalkylene group, or an optionally substituted divalent aralkylene group, the halogenobenzoic acid ester being represented by the following general formula (6): wherein RZ1 represents an alkyl group having 1 to 4 carbon atoms, each RZ2 represents an alkyl group having 1 to 4 carbon atoms or a halogen atom, or any adjacent two RZ2s may form a ring, Hal represents a halogen atom, and n represents 0 to 4, the alcohol compound being represented by the following general formula (7): wherein each RZ2 represents an alkyl group having 1 to 4 carbon atoms or a halogen atom, or any adjacent two RZ2s may form a ring, Hal represents a halogen atom, and n represents 0 to 4.
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