发明名称 |
COMPOUND FOR TREATING CARTILAGE DISORDERS |
摘要 |
<p>The present invention provides a compound of which active form is represented by a formula (A). and which can be injected into a joint cavity which is an affected part of disorders and can be accumulated in the joint cavity to exert the pharmacological effect thereof in a sustained manner, for the purpose of ameliorating cartilage disorders without developing any side effect. A compound according to the present invention, which is represented by a formula (I):
(wherein all of symbols are as defined in the description), is a compound that can achieve the above-mentioned purpose. This compound does not exhibit any side effect on the cardiovascular system even when the compound is administered in an effective amount for exhibiting a cartilage regeneration activity, and is therefore extremely useful as a safe and effective preventive and/or therapeutic agent for cartilage disorders. Since a suspension produced using this compound can be injected without requiring the incision of the affected part, it can reduce the burden on patients, and is extremely useful as a medicinal agent.</p> |
申请公布号 |
EP2740724(A1) |
申请公布日期 |
2014.06.11 |
申请号 |
EP20120822308 |
申请日期 |
2012.08.03 |
申请人 |
ONO PHARMACEUTICAL CO., LTD. |
发明人 |
OBITSU, TETSUO;TANI, KOUSUKE;SUGIHARA, HIKARU;NISHIURA, AKIO;FUJIMURA, SHINSEI |
分类号 |
C07C405/00;A61K9/10;A61K31/5575;A61K47/10;A61K47/26;A61K47/34;A61K47/36;A61K47/40;A61K47/44;A61P19/08;C07C69/732;C07C69/92;C07C235/16 |
主分类号 |
C07C405/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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