发明名称 |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF DEGENERATIVE RETINAL CONDITIONS |
摘要 |
The present invention is directed to compositions and methods for the treatment of degenerative retinal conditions. According to a general aspect, the present invention is directed to inflammatory mediators, preferably components or substrates of the NLRP3-inflammasome, for use in the treatment of degenerative retinal conditions involving drusen and anaphylatoxin-induced choroidal-neovascularisation. The invention is also directed to a method for the treatment of degenerative retinal conditions involving drusen and anaphylatoxin-induced choroidal-neovascularisation and to recombinant vectors and recombinant proteins for use in such methods. The present invention also provides a method for determining the risk of developing or monitoring the progression of diseases involving drusen and anaphylatoxin-induced choroidal neo-vascularisation. |
申请公布号 |
KR20140071455(A) |
申请公布日期 |
2014.06.11 |
申请号 |
KR20147011251 |
申请日期 |
2012.10.01 |
申请人 |
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN |
发明人 |
CAMPBELL MATTHEW;HUMPHRIES PETER;HUMPHRIES MARIAN;KIANG ANNA SOPHIA;DOYLE SARAH;O'NEILL LUKE |
分类号 |
A61K38/20;A61P27/02 |
主分类号 |
A61K38/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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