发明名称 |
NEW USE OF L-HISTIDINE AND DERIVATIVES THEREOF |
摘要 |
The present invention discloses the use of L-Histidine to reduce Gadolinium accumulation into target organs, preventing its toxic effects, after administration of gadolinium based contrast agents. The invention thus, also disclose the use of L-Histidine to prevent the NSF syndrome in patients with renal functionality impairment. A kit of part is also disclosed by the use of which toxicity associated to free Gd 3+ , deriving from GDBCA, is prevented by oral administration of L-histidine at least 1 hour before administration of the contrast agent. A method for the prevention of toxic metal accumulation which consists in the administration, preferably by the oral route, of L-Histidine is also disclosed. L-Histidine is preferably administered as a single oral dose comprised from 0.2-20 g. |
申请公布号 |
EP2739282(A1) |
申请公布日期 |
2014.06.11 |
申请号 |
EP20120737833 |
申请日期 |
2012.07.24 |
申请人 |
BRACCO IMAGING S.P.A |
发明人 |
BARANYAI, ZSOLT;BRÜCHER, ERNÖ;UGGERI, FULVIO;MAIOCCHI, ALESSANDRO;BUSSI, SIMONA |
分类号 |
A61K31/4172;A61P13/12;A61P39/04;A61P43/00 |
主分类号 |
A61K31/4172 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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