The disclosure provides methods and compositions useful for screening inhibitors of aggregation mediated proteotoxicity. The disclosure provides transgenic animals and cell useful for such screening. Also provided are compounds useful for inhibiting aggregation mediated proteotoxicity in a subject.
申请公布号
EP2387567(B1)
申请公布日期
2014.06.11
申请号
EP20100700673
申请日期
2010.01.14
申请人
THE SALK INSTITUTE FOR BIOLOGICAL STUDIES
发明人
DILLIN, ANDREW;BAIGA, THOMAS, J.;KAPERNICK, ERIK;NOEL, JOSEPH, P.