发明名称 |
TREATMENT AND PREVENTION OF DISEASES MEDIATED BY MICROORGANISMS VIA DRUG-MEDIATED MANIPULATION OF THE EICOSANOID BALANCE |
摘要 |
The invention provides a method of enhancing the efficacy of antibiotic treatment of tuberculosis, trypanosomiasis, leprosy, and leishmaniasis involving co-administering to a mammal undergoing antibiotic treatment therapeutically effective amounts of a first compound that is an inhibitor of 5-lipoxygenase and optionally a second compound that is a product of the cyclooxygenase pathways. The invention also provides a pharmaceutical composition comprising an antibiotic, an inhibitor of 5-lipoxygenase, and a product of the cyclooxygenase pathways. |
申请公布号 |
EP2739281(A1) |
申请公布日期 |
2014.06.11 |
申请号 |
EP20120746443 |
申请日期 |
2012.08.02 |
申请人 |
THE U.S.A. AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
MAYER-BARBER, KATRIN;ANDRADE, BRUNO DE BEZERRIL;SHER, ALAN;BARBER, DANIEL LEO |
分类号 |
A61K31/381;A61K31/404;A61K31/41;A61K31/47;A61K31/5575;A61K31/63;A61K45/06;A61P31/06;A61P31/08;A61P33/02 |
主分类号 |
A61K31/381 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|