Heterocyclic piperazine derivatives

摘要

These compounds act as inhibitors of the MAP kinase interacting kinases MNK2a, MNK2b, MNKla, and MNK1b and/or as as ABL or ABL (T315I) inhibitors. The invention further relates to pharmaceutical compositions comprising these compounds, and to the use of the compounds for the prophylaxis and treatment of cancer, diabetes, obesity, inflammatory and Alzheimer disease conditions.