Urinary biomarkers for cancer diagnosis

摘要

The present invention is directed to the field of cancer diagnosis, specifically to the diagnosis of bladder cancer (BC) and prostate cancer (CaP). More specifically, the invention provides simple, non-invasive urinary tests characterized by high sensitivity and specificity, wherein urinary levels of heat shock proteins and anti-inflammatory cytokines are used as biomarkers.

主权项

1. A method for assessing the presence of bladder cancer in a subject suspected of having bladder cancer, said method comprising:
(a) obtaining from the subject a urine sample substantially free of residual cells; (b) determining the level of at least one biomarker in the urine sample, said at least one biomarker being selected from the group consisting of IL-13; HSP60; HSP70; HSP90; and IL-10; (c) comparing the level of said at least one biomarker to a control value or level corresponding to a set of one or more healthy individuals; and (d) determining the presence of bladder cancer in the subject if there is a significant elevation in the level of the at least one biomarker in said urine sample compared to the control value.