| 发明名称 |
Method for the detection of organ or tissue injury |
| 摘要 |
This invention relates to methodology for detecting, assessing and/or diagnosing the presence of organ or tissue injury. More specifically, the present invention relates to methodology for detecting particular serum biomarkers that can be used in the detection, assessment and/or diagnosis of organ (e.g. liver) or tissue (e.g. skin) injury. |
| 申请公布号 |
US8748109(B2) |
申请公布日期 |
2014.06.10 |
| 申请号 |
US201013381238 |
申请日期 |
2010.07.05 |
| 申请人 |
The University of Liverpool |
发明人 |
Antoine Daniel;Williams Dominic;Park Kevin |
| 分类号 |
G01N33/53 |
主分类号 |
G01N33/53 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of detecting and/or assessing hepatic damage or injury associated with administration of a drug to a human or animal subject, the method comprising the steps of
(a) testing a serum sample obtained from said subject for:
(i) a specific serum biomarker of apoptosis;(ii) a specific serum biomarker of necrosis; and(iii) a specific serum biomarker of inflammation; and (b) correlating the presence of said serum biomarkers with a hepatic specific indicator of damage, wherein the serum biomarker of apoptosis is caspase-cleaved K18, the serum biomarker of necrosis is full length K18 and/or the hypoacetylated form of HMGB-1, and the serum biomarker of inflammation is the acetylated form of HMGB-1.
|
| 地址 |
Liverpool GB |
