Compositions and methods for diagnosing and treating melanoma

摘要

Described herein are compositions and methods for the diagnosis, prognosis, prevention and treatment of melanoma or melanoma associated symptoms. The compositions are microRNA molecules associated with melanoma, as well as various nucleic acid molecules relating thereto or derived therefrom.

主权项

1. A method for diagnosing melanoma in a subject comprising:
(a) determining an expression level of a nucleic acid sequence selected from the group consisting of SEQ ID NOS: 1, 5, 7, 8, 12, 14 and sequences at least about 80% identical thereto in a biological sample obtained from the subject; (b) comparing the expression level determined in step (a) to a normal control expression level of the same nucleic acid sequence; (c) diagnosing that the subject has melanoma if the nucleic acid in the sample obtained from the subject is determined in step (b) to have a higher expression level as compared to the normal control expression level; and (d) treating the subject diagnosed in step (c) for melanoma.