Induction of mucosal tolerance to antigens

摘要

Induction of tolerance to antigens by mucosal, preferably oral, delivery of the antigen in combination with an immunomodulating compound producing micro-organism is disclosed. More specifically, Foxp3+ and/or IL-10 and/or TGF-β producing regulatory T-cells are induced which are capable of suppressing undesired immune responses toward an antigen. The antigen is preferably delivered orally in combination with an immunosuppressing cytokine secreting micro-organism.

主权项

1. A composition for treating celiac disease comprising an IL-10 secreting Lactococcus lactis in combination with gliadin, or in combination with a gliadin peptide which binds HLA-DQ2 and/or HLA-DQ8.