Delayed release, oral dosage compositions that contain amorphous CDDO-Me

摘要

Pharmaceutical formulations exhibit a desirably low Cmax, among other properties, that contain particles of amorphous bardoxolone methyl, either in pure form or in the form of a solid dispersion, admixed with particles of a hydrophilic binding agent. Such formulations possess the advantage of higher oral bioavailability, relative to formulations based on the crystalline form of bardoxolone methyl.

主权项

1. A solid dosage form comprising (A) particles consisting of amorphous bardoxolone methyl and a glass-forming excipient admixed with (B) particles consisting of hydroxypropyl methyl cellulose, wherein said particles (A) constitute a therapeutically effective amount of bardoxolone methyl.