| 摘要 |
FIELD: chemistry, pharmacology.SUBSTANCE: invention represents pharmaceutical composition for peroral application and reduction of glucose level in blood, which contains insulin, water-soluble organic acid, water-soluble inert filling agent and auxiliary substance, characterised by the fact that as auxiliary substance it contains sodium carbonate or bicarbonate, and as water-soluble organic acid - citric acid or tartaric acid, or ascorbic acid, or lactic acid, and quantity of sodium carbonate or bicarbonate must be 2-6 times less than the quantity of specified organic acid, with composition components being in specified ratio in wt %.EFFECT: acceleration and simplification of the process of composition application, as well as prevention of undesirable impact of inhibitor of proteolytic enzymes on digestion in small intestine and elimination of risk of penetration of biologically active substance different from insulin into blood, without decrease or with increase of efficiency with reduction of insulin concentration, elimination of risk of temporary increase of glucose level.4 tbl, 5 ex |
