| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to novel derivatives of bicyclic heterocyclic compounds of formula (I), which can be applied in prevention or treatment of abnormal or pathological condition, mediated by FGFR kinase, such as cancer. In formulacompound, (i) in case when Rand Rindependently represent hydrogen or Ccycloalkyl; A is group A, which represents aromatic group, representing phenyl; Rrepresents hydrogen or Calkyl; Rrepresents group R, which represents amino, halogen, Calkyl, -X-R, phenyl or aromatic heterocyclic group, where said heterocyclic group represents 5- or 6-membered heterocyclyl group and contains 1, 2 or 3 heteroatoms, independently selected from nitrogen, oxygen or sulphur, where said phenyl or said heterocyclyl group can be optionally substituted with one or two Rgroups; or (ii) when Rrepresents hydrogen and Rrepresents Calkyl or halogenCalkyl; A is group A, which represents aromatic 5-membered heterocyclic group; Rrepresents hydrogen or Calkyl; Ris group R, which represents halogen; or (iii) when Rrepresents hydrogen and Rrepresents Calkyl or halogenCalkyl; A is group A, which represents aromatic 6-membered heterocyclic group, containing one nitrogen atom as heteroatom; Rrepresents hydrogen or Calkyl; Ris group R, which represents halogen, Calkyl, -X-Ror aromatic heterocyclic group, containing 1, 2 or 3 heteroatoms, independently selected from nitrogen, oxygen and sulphur. Other values of radicals are given in the invention formula.EFFECT: obtaining novel derivatives of bicyclic heterocyclic compounds.21 cl, 7 tbl, 250 ex |
