| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to method of labelling paired helical filaments (PHF), which includes interaction of PHF with compound and detection of said compound presence, where compound has formula, in which -R- stands for, -Q- is selected from: -NHC(O)-, -N=N-, -CH=CH-; -P is selected from:; -T is selected from:; X represents N or CH; -W, -G, -Pare such as given in the invention formula. Invention also relates to method of labelling aggregated tau-protein, which includes interaction of aggregated molecules of tau-protein with compounds and detection of said compound presence, and to compounds of formula, in which values of substituents are such as given in the invention formula.EFFECT: formulacompounds as labels of tau-protein and paired helical filaments (PHF).28 cl, 5 dwg, 225 ex |
