| 发明名称 |
Dosage form with improved release of cefuroximaxetil |
| 摘要 |
The invention relates to a pharmaceutical composition comprising cefuroximaxetil and at least one carrageenan selected from the group consisting of κ-carrageenan, λ-carrageenan and -carrageenan. The invention furthermore relates to pellets, to a multiparticulate, pharmaceutical dosage form and to a novel crystalline modification of cefuroximaxetil. |
| 申请公布号 |
US8747900(B2) |
申请公布日期 |
2014.06.10 |
| 申请号 |
US20060912627 |
申请日期 |
2006.04.25 |
| 申请人 |
Gruenenthal GmbH |
发明人 |
Ziegler Iris;Fischer Andreas |
| 分类号 |
A61K9/16;A61K9/50;A01N59/26;A61K33/42;A61K9/54;A61K31/545 |
主分类号 |
A61K9/16 |
| 代理机构 |
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代理人 |
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| 主权项 |
1. A rapid release cefuroximaxetil pharmaceutical dosage form comprising extruded pellets comprising:
cefuroximaxetil; 20 to 30 wt.-% κ-carrageenan, relative to the total weight of the extruded pellets; tricalcium phosphate; and 1 to 10 wt.-% of sucrose ester relative to the total weight of the extruded pellets;wherein the weight ratio of cefuroximaxetil to κ-carrageenan is in the range from 1.5:1 to 3.5:1;wherein the weight ratio of tricalcium phosphate to κ-carrageenan is in the range from 1:1 to 1:10; andwherein said dosage form releases at least 75% of the cefuroximaxetil within 30 minutes upon exposure to aqueous medium at a pH of 6 to 7.
|
| 地址 |
Aachen DE |
