Pharmacologically active antiviral peptides and methods of their use

摘要

This invention relates to peptides having antiviral properties. The antiviral peptides comprise membrane transiting peptides, and active fragments and derivatives of such peptides. The antiviral peptides exhibit activity against a broad spectrum of viruses, including enveloped and nonenveloped viruses, and are used in pharmaceutical compositions to prevent and/or treat viral infections.

主权项

1. A peptide according to formula 2 (SEQ ID NO: 15)
(X1)n-P-A-V-L-L-A-L-L-A-(X2)m  formula 2 wherein X1 and X2 are selected from one or more charged amino acid residues selected from the group consisting of arginine, lysine and combinations thereof, further wherein n has a value of 0 or 3-10 and m has a value of 0 or 3-10 and wherein either m=0 or n=0.