Inhibitors of yeast filamentous growth and method of their manufacture

摘要

The invention broadly relates to the use of α, β-unsaturated fatty acids to inhibit the filamentous growth of fungi and yeasts and to a method for producing same. In particular the invention relates to the use of optionally substituted C8 to C15 α, β-unsaturated fatty acids or salts, esters or amides thereof for inhibiting or retarding the yeast-to-mycelium transition of organisms having a dimorphic life cycle.

主权项

1. A method of inhibiting or retarding the yeast-to-mycelium transition of an organism having a yeast-to-mycelium dimorphic life cycle, comprising administering to a subject in need thereof at least one optionally substituted C8 to C15 fatty acid or a salt, ester or amide thereof containing only one double bond wherein the double bond is at the α,β-position wherein the fatty acid is 11-methyl-2-dodecenoic acid.