发明名称 |
Lubiprostone crystal, the use and the method for the preparation thereof |
摘要 |
The present invention relates to a lubiprostone crystal, the method for the preparation thereof, and a pharmaceutical composition or kit comprising the same, as well as the use of said crystal in the preparation of a medicament for the treatment of gastrointestinal tract diseases, especially constipation. The X-ray powder diffraction pattern of said crystal comprises characteristic peaks measured at the following 2θ reflection angles: 14.6±0.2°, 17.0±0.2° and 19.6±0.2°. As compared to amorphous lubiprostone, the crystal of the present invention has the advantages of relative high purity, stable properties and easy-for-storage and use. |
申请公布号 |
US8748482(B2) |
申请公布日期 |
2014.06.10 |
申请号 |
US20080935859 |
申请日期 |
2008.05.15 |
申请人 |
Shanghai Techwell Biopharmaceutical Co., Ltd |
发明人 |
Tang Zhijun;Zhuo Zhonghao;Zheng Yunman;He Bingming;Yang Huichun;Zheng Jushang |
分类号 |
A61K31/352;C07D311/96 |
主分类号 |
A61K31/352 |
代理机构 |
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代理人 |
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主权项 |
1. A lubiprostone crystal,
wherein the X-ray powder diffraction pattern of said crystal comprises characteristic peaks measured at the following 2θ reflection angles: 14.6±0.2°, 17.0±0.2° and 19.6±0.2°.
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地址 |
Shanghai CN |