Nanoemulsion therapeutic compositions and methods of using the same

摘要

The present invention relates to methods and compositions for treating pulmonary infection. In particular, the present invention provides nanoemulsion compositions and methods of using the same to treat bacteria associated with biofilms (e.g., found in pulmonary infections). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications.

主权项

1. A method of killing and/or inhibiting growth of bacteria within a biofilm comprising:
A) providing:
i) a biofilm comprising bacteria; andii) a composition comprising:
a) a nanoemulsion; wherein said nanoemulsion comprises:
1) about 3 vol. % to about 15 vol. % of a Poloxamer;2) about 3 vol. % to about 15 vol. % of an organic solvent;3) about 0.5 vol. % to about 1 vol. % of a halogen-containing compound;4) about 3 vol. % to about 90 vol. % of an oil; and5) about 5 vol. % to about 60 vol. % of water;b) ethylenediaminetetraacetic acid (EDTA); andc) a hypertonic salt solution; and B) exposing said biofilm comprising bacteria to said composition under conditions such that said composition kills and/or inhibits growth of said bacteria within said biofilm.