| 发明名称 |
Calicheamicin derivative-carrier conjugates |
| 摘要 |
Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. |
| 申请公布号 |
US8747857(B2) |
申请公布日期 |
2014.06.10 |
| 申请号 |
US20030699874 |
申请日期 |
2003.11.03 |
| 申请人 |
Wyeth Holdings LLC |
发明人 |
Kunz Arthur;Moran Justin Keith;Rubino Joseph Thomas;Jain Neera;Vidunas Eugene Joseph;Simpson John McLean;Merchant Nishith;Dijoseph John Francis;Ruppen Mark Edward;Damle Nitin Krishnaji;Robbins Paul David;Popplewell Andrew George |
| 分类号 |
A61K39/00;C07K16/00 |
主分类号 |
A61K39/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating a subject with a B-cell malignancy that expresses CD22 antigen, the method comprising administering to the subject a therapeutically effective dose of a composition comprising a monomeric cytotoxic drug derivative/anti-CD22 antibody conjugate, wherein the anti-CD22 antibody of the monomeric cytotoxic drug derivative/anti-CD22 antibody conjugate comprises a light chain variable region having the sequence set forth in SEQ ID NO: 19 and a heavy chain variable region having the sequence set forth in SEQ ID NO: 27.
|
| 地址 |
Madison NJ US |
