Methods of treating impaired glucose metabolism via administration of algal biomass

摘要

The invention is directed to methods of using Chlorella protothecoides microalgal biomass in the treatment of individuals having impaired glucose metabolism. In some cases, the patient has impaired fasting glucose, impaired glucose tolerance, or diabetes. In some methods, algal biomass is used to reduce blood glucose and/or body fat in a subject, or to increase the relative abundance of beneficial gut microflora in a subject. In preferred embodiments, the biomass is derived from Chlorella protothecoides cultures grown heterotrophically in which the algal cells comprise at least 15% algal oil by dry weight.

主权项

1. A method of treating a patient having a condition related to impaired glucose metabolism, comprising determining the patient has impaired glucose metabolism and administering to the patient an effective regime of microalgal biomass comprising at least 15% algal oil by dry weight, wherein the microalgal biomass is derived from Chlorella protothecoides and the regime lowers the percentage fat of total body weight in the patient relative to the percentage before the administering step.