发明名称 Copper(I)-ion selective two-photon fluorescent probe for in vivo imaging and method for preparing the same
摘要 PURPOSE: A two-photon dye with high selectivity and sensitivity is provided to have high transmittance depth higher than 90 micron and to detect a monovalent copper ion in a cell for long time without problems of targeting error and discoloration. CONSTITUTION: A two-photon dye with high selectivity and sensitivity is represented by chemical formula 1. In chemical formula 1, R1 is hydrogen, C1-10 alkyl group or C1-10 alkoxy group, R2 is COCH3, a functional group represented by chemical formula 1-a, or a functional group represented by chemical formula 1-b, R3 is hydrogen or C1-10 alkoxy group. A manufacturing method of the two-photon dye comprises a step of reacting a compound represented by chemical formula 3 with a mixture of 6-acetyl-2-[N-methyl-N-(carboxymethyl)amino]naphthalene, 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide to obtain a compound represented by chemical formula 2.
申请公布号 KR101404991(B1) 申请公布日期 2014.06.10
申请号 KR20120111515 申请日期 2012.10.08
申请人 发明人
分类号 A61K49/04;C09B57/00 主分类号 A61K49/04
代理机构 代理人
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