| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to medicine and concerns a liquid formulation of a long-acting conjugate of granulocyte colony stimulating factor (G-CSF) containing a therapeutically effective amount of the long-acting conjugate of granulocyte colony stimulating factor wherein G-CSF is covalently bond to immunoglobulin Fc fragment by a non-peptide polymer, and an albumin-free stabilising agent containing a buffer and mannitol.EFFECT: invention makes the long-acting conjugates of G-CSF having better duration of action and stability in vivo, stay storage-stable for a long period of time.24 cl, 1 dwg, 16 tbl, 8 ex |
