发明名称 COMT INHIBITOR DOSAGE REGIMEN
摘要 FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to using an oxadiazolyl compound of the formula I,wherein Rand Rmean hydrogen; X means a methylene group; Y represents an oxygen atom; n represents an integer of 0, 1, 2 or 3, and m represents an integer of 0 or 1; Rmeans a group of N-oxide pyridine according to the formula B which is attached as shown by an unmarked bond:,wherein R, R, Rand Rare the same or different and mean hydrogen, lower alkyl, halogen, haloalkyl, trifluoromethyl; the term "alkyl" means carbon chains, unbranched or branched, containing one to six carbon atoms; the term "halogen" means fluorine, chlorine, bromine or iodine; or its pharmacologically acceptable salt for preparing a drug for preventing or treating diseases related to the central and peripheral nervous system, wherein the above drug is administered according to a dosage regimen characterised by a dosage rate within approximately twice a day to approximately once every two days.EFFECT: optimising the dosage regimen.84 cl, 3 dwg, 3 ex
申请公布号 RU2518483(C2) 申请公布日期 2014.06.10
申请号 RU20090132188 申请日期 2007.10.10
申请人 BIAL-PORTELA EHND KA, S.A. 发明人 LIRMONT DEHVID ALEKSANDR;KISS LASLO EHRNO;PAL'MA PEDRO NUNO LEAL';FERREJRA UMBERTU DUSH SANTUSH;SILVA PATRISIU MANUEHL VIEHJRA ARAUZHU SUARESH DA
分类号 C07D401/12;A61K31/443;A61K31/4439;A61P25/16;C07D413/12 主分类号 C07D401/12
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