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1. A compound of Formula I:wherein
A is H, —(C═O)—O—R1, —(C═O)—R1, —(C═O)—N(R1R2), —S(O)2—R1, or —S(O)2—N(R1R2), each R1 is independently selected from the group consisting of:
(i) H, aryl; substituted aryl; heteroaryl; substituted heteroaryl;(ii) heterocycloalkyl or substituted heterocycloalkyl; and(iii) —C1-C8 alkyl, —C2-C8 alkenyl or —C2-C8 alkynyl, each containing 0, 1, 2, or 3 heteroatoms independently selected from O, S, and N; substituted —C1-C8 alkyl, substituted —C2-C8 alkenyl or substituted —C2-C8 alkynyl, each containing 0, 1, 2, or 3 heteroatoms independently selected from O, S and N; —C3-C12 cycloalkyl, substituted —C3-C12 cycloalkyl; —C3-C12 cycloalkenyl, or substituted —C3-C12 cycloalkenyl; each R2 is independently selected from the group consisting of:
(i) hydrogen;(ii) aryl; substituted aryl; heteroaryl; substituted heteroaryl;(iii) heterocycloalkyl or substituted heterocycloalkyl; and(iv) —C1-C8 alkyl, —C2-C8 alkenyl or —C2-C8 alkynyl, each containing 0, 1, 2, or 3 heteroatoms independently selected from O, S, and N; substituted —C1-C8 alkyl, substituted —C2-C8 alkenyl or substituted —C2-C8 alkynyl, each containing 0, 1, 2, or 3 heteroatoms independently selected from O, S and N; —C3-C12 cycloalkyl, substituted —C3-C12 cycloalkyl; —C3-C12 cycloalkenyl, or substituted —C3-C12 cycloalkenyl; G is —NHS(O)2—R3; each R3 is independently selected from:
(i) C3-C12 cycloalkyl, substituted —C3-C12 cycloalkyl, aryl; substituted aryl; heteroaryl; substituted heteroaryl;(ii) heterocycloalkyl or substituted heterocycloalkyl; and(iii) —C1-C8 alkyl, —C2-C8 alkenyl or —C2-C8 alkynyl, each containing 0, 1, 2, or 3 heteroatoms independently selected from O, S, and N; substituted —C1-C8 alkyl, substituted —C2-C8 alkenyl or substituted —C2-C8 alkynyl, each containing 0, 1, 2, or 3 heteroatoms independently selected from O, S and N; —C3-C12 cycloalkenyl, or substituted —C3-C12 cycloalkenyl; and L is a C2-C5 saturated or unsaturated chain, optionally containing one to three heteroatoms independently selected from O, N and S(O)n, wherein L is optionally substituted with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, cyano, C1-C6alkyl, C2-C6alkenyl and C2-C6alkynyl, wherein each C1-C6alkyl, C2-C6alkenyl and C2-C6alkynyl, group is optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl and cyano; Z is (i) —C1-C8 alkyl containing 0, 1, 2, or 3 heteroatoms independently selected from O, S, and N and optionally substituted with one or more halo; or (ii) thienyl or substituted thienyl; j=0, 1, 2, 3, or 4; k=0, 1, 2, or 3; m=0, 1, or 2; n is 0, 1, or 2; denotes a carbon-carbon single or double bond (i.e.,meansR6 is H or halo;R7 is H or halo;R8 is H or halo;R9 is H or halo;
wherein if each of R6, R7, R8 and R9 is H, then Z is —C1-C8 alkyl substituted with one or more halo and containing 0, 1, 2, or 3 heteroatoms independently selected from O, S, and N; andsalts, solvates and hydrates thereof.
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