| 发明名称 |
Drug delivery system |
| 摘要 |
A drug delivery system for the controlled release of a pharmaceutically-active compound by oral route comprises an intercalate of a layered double hydroxide having, before intercalation, layers of metal hydroxides, and having intercalated therein a pharmaceutically-active compound having at least one anionic group. A preferred layered double hydroxide is one that has layers which comprise [LiAl2(OH)6]+. The drug delivery system has use in the delivery of drugs such as 4-biphenylacetic acid, Diclofenac, Gemfibrozil, Ibuprofen, Naproxen, 2-Propylpentanoic acid and Tolfenamic acid. |
| 申请公布号 |
US8747912(B2) |
申请公布日期 |
2014.06.10 |
| 申请号 |
US20080011773 |
申请日期 |
2008.01.28 |
| 申请人 |
Isis Innovation Limited |
发明人 |
O'Hare Dermot Michael |
| 分类号 |
A61K9/14;A61K31/19;A61K31/192;A61K31/196;A61K33/08;A61K33/10 |
主分类号 |
A61K9/14 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A drug delivery system comprising an intercalate of a layered double hydroxide having, before intercalation, layers of metal hydroxides, and having intercalated therein a pharmaceutically-active compound having at least one anionic group, wherein said intercalate is present in an oral dosage formulation, and which additionally comprises a non-toxic compound having an anion which is capable of displacing the pharmaceutically-active compound from the intercalate, wherein the non-toxic compound is selected from magnesium carbonate, magnesium hydrogen carbonate, calcium carbonate and calcium hydrogen carbonate.
|
| 地址 |
Oxford GB |
