| 发明名称 |
Sequence of reverse transcriptase gene and method of use |
| 摘要 |
The present invention provides an isolated polynucleotide acid comprising a polynucleotide sequence having a substantial amount of sequence identity to the entire length of the polynucleotide sequence as set forth in SEQ ID NO: 1 or its complementary strand (SEQ ID NO: 2), the sequence is derived from RT domain of HBV polymerase gene. The present invention also provides a polypeptide and related compositions, as well as methods for using the same. |
| 申请公布号 |
US8748087(B2) |
申请公布日期 |
2014.06.10 |
| 申请号 |
US20060614062 |
申请日期 |
2006.12.20 |
| 申请人 |
Fudan University |
发明人 |
Wen Yu-Mei;Wang Yong-Xiang;Ma Zhang-Mei |
| 分类号 |
C12Q1/70;C12Q1/68;C12Q1/18;A61K49/00 |
主分类号 |
C12Q1/70 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method to screen for anti-HBV agents which are inhibitors to HBV replication, comprising: evaluating a substance for ability to bind to an amino acid sequence with at least 50% identity to SEQ ID NO: 3 in a helix-turn-helix structure, using molecular modeling or reaction of the substance with the amino acid sequence, and, if the substance is evaluated as able to bind, testing the substance for inhibitory effects on HBV replication.
|
| 地址 |
Shanghai CN |
