摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to formulacompound or to its pharmaceutically acceptable salt, where R represents COOH or CHOH. Invention also relates to pharmaceutical composition based on formula I, method of modulating CFTR activity in biological sample, based on application of formula I compound, method of treatment, based on application of formula I compound, set based on formula I compound.EFFECT: obtained are novel derivatives of quinolin-4-one, useful as CFTR modulators.18 cl, 1 tbl, 8 ex |