| 摘要 |
FIELD: medicine.SUBSTANCE: group of inventions is based on modulation of Hedgehog signalling transduction pathways. In more detail, the group of inventions refers to methods of treating Hedgehog related cancer. Particularly, the application describes methods of inhibition of abnormal growth conditions caused by such phenotypes, as loss of the Ptch function, dominant-negative intensification of the Hedgehog function, dominant-negative intensification of the Smoothened function or dominant-negative intensification of the Gli function consisting in administering a combination containing Smoothened inhibitors and Gli inhibitors or phosphatidylinositol-3-kinase (PI3K) inhibitors into a mammal.EFFECT: group of inventions enables treating Hedgehog-related cancers effectively.6 cl, 4 tbl, 2 ex, 9 dwg |
