Xylose-fermenting microorganism

摘要

The present disclosure provides compositions and methods related to the fermentation of xylose. Host cells having recombinant polynucleotides encoding one or more of aldose reductases, xylitol dehydrogenases, and xylulokinase are provided herein. Host cells having reduced expression of PHO13 are also provided herein. Also provided herein are uses of host cells provided herein, and methods relating to the use of xylose-containing materials.

主权项

1. A host cell comprising:
a) a recombinant polynucleotide encoding an aldose reductase comprising an amino acid sequence having at least 90% identity to SEQ ID NO: 2; b) a recombinant polynucleotide encoding a xylitol dehydrogenase comprising an amino acid sequence having at least 90% identity to SEQ ID NO: 6; and c) a recombinant polynucleotide encoding a xylulokinase comprising an amino acid sequence having at least 90% identity to SEQ ID NO: 8.