Statin nanoparticles

摘要

The present invention relates to a complex made up of at least one molecule of statin or a derivative thereof, covalently bonded to at least one hydrocarbon radical including at least 18 carbon atoms and containing at least one 2-methyl-buta-2-ene unit, to nanoparticles of such a complex, and to a method for preparing same, said complex and/or said nanoparticles optionally being in the form of a lyophilizate. The present invention also relates to a pharmaceutical composition including at least one complex and/or nanoparticles such as previously defined. The invention finally relates to said complex and/or to said nanoparticles for the treatment and/or prevention of hyperlipemia and hypercholesterolemia.

主权项

1. A complex made up of (i) at least one molecule of statin or a derivative thereof, said molecule comprising a 4-hydroxy-6-oxo-2H-pyran system or a dihydroxy acid form thereof, and a lipophilic part presenting an aryl, an heteroaryl or a 1,2,6,7,8,8a-hexahydronaphtyl group, optionally substituted, and said molecule being covalently coupled to (ii) at least one hydrocarbon-based radical comprising at least 18 carbon atoms and containing at least one unit represented by the formula which follows: