| 发明名称 |
Nuclear targeting sequences |
| 摘要 |
Isolated peptides comprising nuclear targeting activity or being capable of preventing endogenous nuclear targeting activity are disclosed. Polynucleotides encoding same, pharmaceutical compositions comprising same, as well as uses thereof are also disclosed. |
| 申请公布号 |
US8748371(B2) |
申请公布日期 |
2014.06.10 |
| 申请号 |
US20080528465 |
申请日期 |
2008.02.28 |
| 申请人 |
Yeda Research and Development Co. Ltd. |
发明人 |
Seger Rony;Chuderland Dana |
| 分类号 |
A61K38/00;A61K47/00;A61K38/04;C07K5/00;C07K7/00;C07K16/00;C07K17/00;C07H21/02 |
主分类号 |
A61K38/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated peptide comprising an amino acid sequence at least 70% homologous to the sequence as set forth by:(SEQ ID NO: 4)L D Q L N H I L G I L G X1 P X2 Q E D; wherein X1 and X2 is not serine, the isolated peptide being capable of preventing ERK nuclear translocation, wherein the peptide is less than 20 amino acids.
|
| 地址 |
Rehovot IL |
