3-ALKYLIDENEHYDRAZINO SUBSTITUTED HETEROARYL COMPOUNDS AS THROMBOPOIETIN RECEPTOR ACTIVATORS

摘要

A compound represented by the formula (1): wherein A is a nitrogen atom or CR⁴, B is an oxygen atom, a sulfur atom or NR⁹ (provided that when A is a nitrogen atom, B is not NH), R¹ is a C_2-14 aryl group, L¹ is a bond, CR¹⁰R¹¹, an oxygen atom, a sulfur atom or NR¹², X is OR¹³ SR¹³ or NR¹⁴NR¹⁵, R² is a hydrogen atom, a formyl group, a C_1-10 alkyl group or the like, L² is a bond or the like, L³ is a bond, CR¹⁷R¹⁸, an oxygen atom, a sulfur atom or NR¹⁹, L⁴ is a bond, CR²⁰R²¹, an oxygen atom, a sulfur atom or NR²², Y is an oxygen atom, a sulfur atom or NR²³, and R³ is a C_2-14 aryl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.