发明名称 |
Antagonistas de IL-17A, IL-17F e IL-23P19 y procedimientos de uso |
摘要 |
There is provided an antagonist of IL-23 and of IL-17A or IL-17F comprising: (i) an antibody or antibody fragment that binds the p19 subunit of IL-23 as shown in SEQ ID NO: 4; and (ii) an antibody or antibody fragment that binds IL-17A as shown in SEQ ID NO: 2 or that binds IL-17F as shown in SEQ ID NO: 6; wherein the antibody or antibody fragment that binds IL-17A or IL-17F comprises a HCDR1 amino acid sequence, a HCDR2 amino acid sequence, and a HCDR3 amino acid sequence of the variable heavy region selected from the group consisting of the variable heavy region of the hybridoma of ATCC Patent Deposit Designation PTA-7988; and wherein the variable light region comprises a LCDR1 amino acid sequence, a LCDR2 amino acid sequence, and a LCDR3 amino acid sequence of the variable light region of the hybridoma of ATCC Patent Deposit Designation PTA-7988. |
申请公布号 |
ES2465223(T3) |
申请公布日期 |
2014.06.05 |
申请号 |
ES20110168730T |
申请日期 |
2008.04.28 |
申请人 |
ZYMOGENETICS, INC. |
发明人 |
LEWIS, KATHERINE E.;PRESNELL, SCOTT R.;LEVIN, STEVEN D. |
分类号 |
C07K16/24;A61K39/395;A61P37/06;C07K16/46 |
主分类号 |
C07K16/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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