| 摘要 |
Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders. |
| 主权项 |
1. A compound of formula (I):or an enantiomer, a mixture of enantiomers, or a mixture of two or more diastereomers thereof;or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof; wherein:
X is NH, and Y is S(O)2; or X is S(O)2, and Y is NH; R′ is hydrogen, halogen, cyano, OH, OC(O)Ra, C(O)Ra, C(O)ORa, C(O)NRaRb, NRaC(O)Rb, NRaRb, OS(O)Ra, SRa, S(O)Ra, S(O)2Ra, S(O)2NRaRb, NRaS(O)2Rb, (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C1-C8)alkoxy, (C2-C8)alkenyloxy, (C2-C8)alkynyloxy, (C3-C8)cycloalkyl, or (C3-C8)cycloalkyloxy, wherein the alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy, cycloalkyl, and cycloalkyloxy are each optionally substituted with one or more halogen; n is 2, 3, or 4; each occurrence of R is independently hydrogen, (C1-C6)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, or (C3-C8)cycloalkyl, each of which is optionally substituted with one or more halogen; and Ra and Rb are each independently hydrogen, (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C1-C8)heteroalkyl, (C3-C8)cycloalkyl, (C7-C12)aralkyl, phenyl, (5 to 6 membered)heteroaryl, or (3 to 7 membered)heterocyclyl; or Ra and Rb together form a 3 to 10 membered ring.
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