COMPOUND CONTAINING PYRIDINE RING AND METHOD FOR PRODUCING HALOGENATED PICOLINE DERIVATIVE AND TETRAZOLYLOXIME DERIVATIVE

摘要

Disclosed is a compound containing a pyridine ring;;that can be synthesized in an industrially advantageous manner, and is useful as an intermediate for producing tetrazolyloxime derivatives that exhibit fungicidal activity (wherein R0 represents a C1-6 alkoxy group, C1-6 alkoxy-C1-6 alkoxy group or the like, R1 represents a C1-2 alkoxycarbonyl group, acetyl group or the like, Z represents a halogen atom, cyano group or the like, X represents a halogen atom, and n represents an integer of 0 to 3), and industrially advantageous production methods for producing 2-substituted amino-6-halomethylpyridine derivatives and tetrazolyloxime derivatives.

主权项

1. A method for producing a brominated picoline derivative represented by formula (6), the method comprising reacting a brominated picoline derivative represented by formula (4) and/or formula (5), a phosphite ester, and a base in an organic solvent,wherein R1b represents an unsubstituted or substituent-containing alkoxycarbonyl group,
R2b represents an unsubstituted or substituent-containing alkoxycarbonyl group, an unsubstituted or substituent-containing acyl group, an unsubstituted or substituent-containing aryloxycarbonyl group, or an unsubstituted or substituent-containing heterocyclic oxycarbonyl group, Z represents a halogen atom, a cyano group, a nitro group, a hydroxyl group, a thiol group, a formyl group, a carboxyl group, an unsubstituted or substituent-containing amino group, an unsubstituted or substituent-containing alkyl group, an unsubstituted or substituent-containing alkenyl group, an unsubstituted or substituent-containing alkynyl group, an unsubstituted or substituent-containing aryl group, an unsubstituted or substituent-containing heterocyclic group, OR3, S(O)pR3, COR3 or CO2R3 (wherein R3 represents an unsubstituted or substituent-containing amino group, an unsubstituted or substituent-containing alkyl group, an unsubstituted or substituent-containing alkenyl group, an unsubstituted or substituent-containing alkynyl group, an unsubstituted or substituent-containing aryl group, or an unsubstituted or substituent-containing heterocyclic group, and p represents a number of oxygen atoms in parentheses, and is an integer of 0 to 2), and m represents a number of Z substituents and is an integer of 0 to 3, and when m is 2 or more, a plurality of the Z substituents may be identical to, or different from, each other.