发明名称 ENHANCERS OF INDUCED PLURIPOTENT STEM CELL REPROGRAMMING
摘要 Described herein, inter alia, are methods and compositions useful for induced pluripotent stem cell reprogramming.
申请公布号 US2014154805(A1) 申请公布日期 2014.06.05
申请号 US201314054551 申请日期 2013.10.15
申请人 City of Hope 发明人 Shi Yanhong;Yip Man Lun;Li Wendong
分类号 C12N5/074 主分类号 C12N5/074
代理机构 代理人
主权项 1. A method of expressing an Oct4 protein in a cell, the method comprising (i) contacting a cell with a compound having the formula: wherein, X1 is C(R12) or N; X2 is C(R4) or N; X3 is C(R5) or N; R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are independently selected from hydrogen, halogen, —CN, —NO2, —NH2, —CF3, —CCl3, —OH, —SH, —SO3H, —C(O)OH, —C(O)NH2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl, wherein R2 and R3 are optionally joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; and (ii) after step (i), allowing said cell to express an Oct4 protein.
地址 Duarte CA US
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