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1. A method for improving cognition and/or treating a cognitive disorder comprising co-administering to a subject a therapeutically effective amount of (1) a tobacco-free nicotine dosage; and (2) a compound of formula (I), or a pharmaceutically acceptable salt thereof,wherein
R1 is 1-azabicyclo[2.2.2]oct-3-yl, R2 is hydrogen or (C1-C6)alkyl, R3 is hydrogen, halogen or (C1-C6)alkyl, A is oxygen or sulfur, and Z is halogen, formyl, carbamoyl, cyano, trifluoromethyl, trifluoromethoxy, nitro, amino, formamido, acetamido, (C1-C6)alkyl, (C1-C6)alkyoxy, (C1-C6)alkylthio, (C1-C6)alkylamino, heteroaryl-carbonylamino, arylcarbonylamino, (C1-C4)alkylsulfonylamino, di(arylsulfonyl)amino, (C3-C6)cycloalkylcarbonylmethyl or amino(hydroxyimino)methyl.
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