发明名称 PROCESSES FOR THE PREPARATION OF ENAMINES
摘要 The invention disclosed in this document is related to the field of processes for the preparation of enamines;;wherein R1, R2, R3, R4, R5, and further information are disclosed herein.
申请公布号 US2014155629(A1) 申请公布日期 2014.06.05
申请号 US201414172516 申请日期 2014.02.04
申请人 Bland Douglas C.;Toyzan Todd W. 发明人 Bland Douglas C.;Toyzan Todd W.
分类号 C07D295/084 主分类号 C07D295/084
代理机构 代理人
主权项 1. A process to produce 1-(3-methylsulfanyl-but-1-enyl)-pyrrolidine said process comprising: (A) reacting, in a reaction zone that comprises solvents, pyrrolidine and 3-methylsulfanyl-butyraldehyde to produce 1-(3-methylsulfanyl-but-1-enyl)-pyrrolidine and H2O, wherein said reacting, in said reaction zone, is conducted under azeotropic distillation conditions comprising (1) a pressure from about 5000 Pascals (Pa) to about 15,000 Pa, and(2) a temperature from about 25° C. to about 65° C.; and wherein said solvents are initially toluene and acetonitrile, and then H2O, where said H2O is produced from the condensation of said pyrrolidine and said 3-methylsulfanyl-butyraldehyde to produce said 1-(3-methylsulfanyl-but-1-enyl)-pyrrolidine, thereby forming a ternary azeotrope of toluene, acetonitrile, and H2O; and (B) removing a vapor phase from said reaction zone wherein said vapor phase comprises H2O; wherein said process no desiccants are used to remove H2O; wherein said process said molar ratio of pyrrolidine to 3-methylsulfanyl-butyraldehyde is greater than 1 but less than about 1.1.
地址 Midland MI US