发明名称 |
COMBINATIONS OF METFORMIN WITH OTHER COMPOUNDS FOR THE TREATMENT OF CANCER AND FOR IMMUNOSUPPRESSION |
摘要 |
The invention relates to combinations of metformin or related biguanides such as phenformin, buformin or proguanil, with particular metformin sensitizing compounds that have the capability to sensitize rapidly proliferating cells to metformin or related biguanides in such a way that combinations cause cell lethality at concentrations where neither metformin alone nor such metformin sensitizing compounds alone exert appreciable cell lethality. The invention further relates to the use of such combinations in the treatment of cancer and for achieving immunosuppression. |
申请公布号 |
WO2014083095(A1) |
申请公布日期 |
2014.06.05 |
申请号 |
WO2013EP74945 |
申请日期 |
2013.11.28 |
申请人 |
UNIVERSITAET BASEL |
发明人 |
COLOMBI, MARCO;BENJAMIN, DON;HALL, MICHAEL;MORONI, CHRISTOPH |
分类号 |
A61K31/155;A61K31/235;A61K31/41;A61K31/4184;A61K31/426;A61K31/427;A61K31/428;A61K31/4709;A61K31/513;A61K31/519;A61K31/5375;A61P35/00;A61P37/06 |
主分类号 |
A61K31/155 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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