发明名称 |
PROGRANULIN AS MARKER FOR AUTOIMMUNE DISORDERS |
摘要 |
The present invention provides for means and method for the detection and/or the quantification of anti-progranulin-autoantibodies in a biological sample of a subject. The present invention also provides for means and method for the detection and/or the quantification of hyper-phosphorylated progranulin in a biological sample of a subject. The present invention further provides for means and methods for the detection of an aberrant conversion pathway of progranulin into granulines in a biological sample of a subject. In fact, the presence of anti-progranulin-autoantibodies and/or hyper-phosphorylated progranulin and/or an aberrant conversion pathway may be indicative that the subject may be suffering from an autoimmune disorder. |
申请公布号 |
WO2014083040(A2) |
申请公布日期 |
2014.06.05 |
申请号 |
WO2013EP74829 |
申请日期 |
2013.11.27 |
申请人 |
UNIVERSITAET DES SAARLANDES |
发明人 |
PFREUNDSCHUH, MICHAEL;PREUSS, KLAUS-DIETER;THURNER, LORENZ |
分类号 |
A61K38/00;A61K39/00;C07K14/47;C07K16/00;G01N33/564;G01N33/68 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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