发明名称 |
METHODS OF MEASURING ADAMTS 13-MEDIATED IN VIVO CLEAVAGE OF VON WILLEBRAND FACTOR AND USES THEREOF |
摘要 |
The invention generally relates to methods of measuring cleaved von Willebrand factor (VWF) fragments. More specifically, the invention relates to methods of measuring the ability of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) to cleave VWF in vivo. The invention also relates to methods of using various animal models which demonstrate ADAMTS13 activity similar to that of a human. The invention further relates to methods of measuring the cleavage products of rVWF in mammals, particularly in humans and in human plasma. |
申请公布号 |
US2014154709(A1) |
申请公布日期 |
2014.06.05 |
申请号 |
US201314078324 |
申请日期 |
2013.11.12 |
申请人 |
BAXTER HEALTHCARE SA ;BAXTER INTERNATIONSL INC. |
发明人 |
Varadi Katalin;Rottensteiner Hanspeter;Turecek Peter;Schwarz Hans-Peter;Schreiner Jutta |
分类号 |
G01N33/86 |
主分类号 |
G01N33/86 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Glattpark (Opifkon) CH |